Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fgf8  fibroblast growth factor 8   (Synonyms: Aigf, Fgf-8)
Results	Reference
1*	J:82633 Adamska M, MacDonald BT, Meisler MH, Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb. Dev Biol. 2003 Mar 15;255(2):350-62
1	J:73526 Ahn K, Mishina Y, Hanks MC, Behringer RR, Crenshaw EB 3rd, BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb. Development. 2001 Nov;128(22):4449-61
1	J:207610 Akiyama R, Kawakami H, Taketo MM, Evans SM, Wada N, Petryk A, Kawakami Y, Distinct populations within Isl1 lineages contribute to appendicular and facial skeletogenesis through the beta-catenin pathway. Dev Biol. 2014 Mar 1;387(1):37-48
1	J:145732 Aoto K, Shikata Y, Imai H, Matsumaru D, Tokunaga T, Shioda S, Yamada G, Motoyama J, Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol. 2009 Mar 1;327(1):106-20
1	J:105980 Arnold JS, Werling U, Braunstein EM, Liao J, Nowotschin S, Edelmann W, Hebert JM, Morrow BE, Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development. 2006 Mar;133(5):977-87
1	J:88851 Aulehla A, Wehrle C, Brand-Saberi B, Kemler R, Gossler A, Kanzler B, Herrmann BG, Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell. 2003 Mar;4(3):395-406
1*	J:83881 Bell SM, Schreiner CM, Hess KA, Anderson KP, Scott WJ, Asymmetric limb malformations in a new transgene insertional mutant, footless. Mech Dev. 2003 May;120(5):597-605
1*	J:49210 Bell SM, Schreiner CM, Scott WJ, The loss of ventral ectoderm identity correlates with the inability to form an AER in the legless hindlimb bud. Mech Dev. 1998 Jun;74(1-2):41-50
1*	J:86196 Bell SM, Schreiner CM, Waclaw RR, Campbell K, Potter SS, Scott WJ, Sp8 is crucial for limb outgrowth and neuropore closure. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12195-200
1*	J:111066 Brown D, Yu BD, Joza N, Benit P, Meneses J, Firpo M, Rustin P, Penninger JM, Martin GR, Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9918-23
1	J:171520 Compagnucci C, Fish JL, Schwark M, Tarabykin V, Depew MJ, Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center. Genesis. 2011 Apr;49(4):307-25
1*	J:49808 Crackower MA, Motoyama J, Tsui LC, Defect in the maintenance of the apical ectodermal ridge in the Dactylaplasia mouse. Dev Biol. 1998 Sep 1;201(1):78-89
1*	J:47920 Dattani MT, Martinez-Barbera JP, Thomas PQ, Brickman JM, Gupta R, Martensson IL, Toresson H, Fox M, Wales JK, Hindmarsh PC, Krauss S, Beddington RS, Robinson IC, Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet. 1998 Jun;19(2):125-33
1	J:311931 Duboc V, Sulaiman FA, Feneck E, Kucharska A, Bell D, Holder-Espinasse M, Logan MPO, Tbx4 function during hindlimb development reveals a mechanism that explains the origins of proximal limb defects. Development. 2021 Oct 1;148(19):dev199580
1	J:90261 Dupe V, Matt N, Garnier JM, Chambon P, Mark M, Ghyselinck NB, A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14036-41
1	J:51455 Gofflot F, Hall M, Morriss-Kay GM, Genetic patterning of the posterior neuropore region of curly tail mouse embryos: deficiency of Wnt5a expression. Int J Dev Biol. 1998 Jul;42(5):637-44
1	J:259795 Green RM, Fish JL, Young NM, Smith FJ, Roberts B, Dolan K, Choi I, Leach CL, Gordon P, Cheverud JM, Roseman CC, Williams TJ, Marcucio RS, Hallgrimsson B, Developmental nonlinearity drives phenotypic robustness. Nat Commun. 2017 Dec 6;8(1):1970
1	J:220655 Harmacek L, Watkins-Chow DE, Chen J, Jones KL, Pavan WJ, Salbaum JM, Niswander L, A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice. Dev Neurobiol. 2014 May;74(5):483-97
1	J:193728 Hong M, Krauss RS, Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. PLoS Genet. 2012;8(10):e1002999
1	J:143538 Hu D, Marcucio RS, Unique organization of the frontonasal ectodermal zone in birds and mammals. Dev Biol. 2009 Jan 1;325(1):200-10
1	J:184018 Itou J, Kawakami H, Quach T, Osterwalder M, Evans SM, Zeller R, Kawakami Y, Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos. Development. 2012 May;139(9):1620-9
1	J:232412 Jeon S, Seong RH, Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway. PLoS Genet. 2016 Mar;12(3):e1005915
1	J:187010 Jiang X, Zhou Y, Xian L, Chen W, Wu H, Gao X, The mutation in chd7 causes misexpression of bmp4 and developmental defects in telencephalic midline. Am J Pathol. 2012 Aug;181(2):626-41
1	J:178771 Kawakami Y, Marti M, Kawakami H, Itou J, Quach T, Johnson A, Sahara S, O'Leary DD, Nakagawa Y, Lewandoski M, Pfaff S, Evans SM, Izpisua Belmonte JC, Islet1-mediated activation of the beta-catenin pathway is necessary for hindlimb initiation in mice. Development. 2011 Oct;138(20):4465-73
1	J:165721 Krawchuk D, Weiner SJ, Chen YT, Lu BC, Costantini F, Behringer RR, Laufer E, Twist1 activity thresholds define multiple functions in limb development. Dev Biol. 2010 Nov 1;347(1):133-46
1	J:86477 Lebel M, Agarwal P, Cheng CW, Kabir MG, Chan TY, Thanabalasingham V, Zhang X, Cohen DR, Husain M, Cheng SH, Bruneau BG, Hui CC, The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice. Mol Cell Biol. 2003 Nov;23(22):8216-25
1*	J:138715 Li WY, Dudas M, Kaartinen V, Signaling through Tgf-beta type I receptor Alk5 is required for upper lip fusion. Mech Dev. 2008 Sep-Oct;125(9-10):874-82
1*	J:76546 Lin W, Furthauer M, Thisse B, Thisse C, Jing N, Ang SL, Cloning of the mouse Sef gene and comparative analysis of its expression with Fgf8 and Spry2 during embryogenesis. Mech Dev. 2002 May;113(2):163-8
1	J:81581 Liu C, Nakamura E, Knezevic V, Hunter S, Thompson K, Mackem S, A role for the mesenchymal T-box gene Brachyury in AER formation during limb development. Development. 2003 Apr;130(7):1327-37
1	J:97214 Liu W, Sun X, Braut A, Mishina Y, Behringer RR, Mina M, Martin JF, Distinct functions for Bmp signaling in lip and palate fusion in mice. Development. 2005 Mar;132(6):1453-61
1	J:79482 Liu Y, Liu C, Yamada Y, Fan CM, growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb. Development. 2002 Nov;129(22):5289-300
1	J:213641 Lopez-Rios J, Duchesne A, Speziale D, Andrey G, Peterson KA, Germann P, Unal E, Liu J, Floriot S, Barbey S, Gallard Y, Muller-Gerbl M, Courtney AD, Klopp C, Rodriguez S, Ivanek R, Beisel C, Wicking C, Iber D, Robert B, McMahon AP, Duboule D, Zeller R, Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs. Nature. 2014 Jul 3;511(7507):46-51
1*	J:28252 Mahmood R, Bresnick J, Hornbruch A, Mahony C, Morton N, Colquhoun K, Martin P, Lumsden A, Dickson C, Mason I, A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr Biol. 1995 Jul 1;5(7):797-806
1*	J:80020 Marcil A, Dumontier E, Chamberland M, Camper SA, Drouin J, Pitx1 and Pitx2 are required for development of hindlimb buds. Development. 2003 Jan;130(1):45-55
1	J:91163 Mic FA, Sirbu IO, Duester G, Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation. J Biol Chem. 2004 Jun 18;279(25):26698-706
1	J:90991 Michos O, Panman L, Vintersten K, Beier K, Zeller R, Zuniga A, Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development. 2004 Jul;131(14):3401-10
1*	J:41974 Neubuser A, Peters H, Balling R, Martin GR, Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell. 1997 Jul 25;90(2):247-55
1*	J:135997 Nie X, Deng CX, Wang Q, Jiao K, Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev Biol. 2008 Apr 15;316(2):417-30
1	J:206578 Nonomura K, Yamaguchi Y, Hamachi M, Koike M, Uchiyama Y, Nakazato K, Mochizuki A, Sakaue-Sawano A, Miyawaki A, Yoshida H, Kuida K, Miura M, Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells. Dev Cell. 2013 Dec 23;27(6):621-34
1*	J:21078 Ohuchi H, Yoshioka H, Tanaka A, Kawakami Y, Nohno T, Noji S, Involvement of androgen-induced growth factor (FGF-8) gene in mouse embryogenesis and morphogenesis. Biochem Biophys Res Commun. 1994 Oct 28;204(2):882-8
1	J:158139 Seifert AW, Yamaguchi T, Cohn MJ, Functional and phylogenetic analysis shows that Fgf8 is a marker of genital induction in mammals but is not required for external genital development. Development. 2009 Aug;136(15):2643-51
1	J:197026 Sheth R, Gregoire D, Dumouchel A, Scotti M, Pham JM, Nemec S, Bastida MF, Ros MA, Kmita M, Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth. Development. 2013 May;140(10):2130-8
1*	J:276703 Shi J, Gao Q, Cao Y, Fu J, Dennd1a, a susceptibility gene for polycystic ovary syndrome, is essential for mouse embryogenesis. Dev Dyn. 2019 May;248(5):351-362
1	J:78402 Sun X, Mariani FV, Martin GR, Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature. 2002 Aug 1;418(6897):501-8
1	J:212416 Thomas PS, Rajderkar S, Lane J, Mishina Y, Kaartinen V, AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity. Dev Biol. 2014 Jun 15;390(2):191-207
1	J:86325 Treichel D, Schock F, Jackle H, Gruss P, Mansouri A, mBtd is required to maintain signaling during murine limb development. Genes Dev. 2003 Nov 1;17(21):2630-5
1	J:101736 Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X, Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development. 2005 Oct;132(19):4235-45
1	J:185554 Wu CI, Hoffman JA, Shy BR, Ford EM, Fuchs E, Nguyen H, Merrill BJ, Function of Wnt/beta-catenin in counteracting Tcf3 repression through the Tcf3-beta-catenin interaction. Development. 2012 Jun;139(12):2118-29
1	J:272581 Wymeersch FJ, Skylaki S, Huang Y, Watson JA, Economou C, Marek-Johnston C, Tomlinson SR, Wilson V, Transcriptionally dynamic progenitor populations organised around a stable niche drive axial patterning. Development. 2019 Jan 2;146(1):dev168161
1	J:46380 Xu X, Weinstein M, Li C, Naski M, Cohen RI, Ornitz DM, Leder P, Deng C, Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development. 1998 Feb;125(4):753-65
1	J:122561 Zakany J, Zacchetti G, Duboule D, Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10. Dev Biol. 2007 Jun 15;306(2):883-93
1	J:170604 Zhang Z, O'Rourke JR, McManus MT, Lewandoski M, Harfe BD, Sun X, The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol. 2011 Mar 15;351(2):254-65
1	J:213417 Zhulyn O, Li D, Deimling S, Vakili NA, Mo R, Puviindran V, Chen MH, Chuang PT, Hopyan S, Hui CC, A switch from low to high Shh activity regulates establishment of limb progenitors and signaling centers. Dev Cell. 2014 Apr 28;29(2):241-9
1*	J:218166 Zhulyn O, Nieuwenhuis E, Liu YC, Angers S, Hui CC, Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development. Dev Biol. 2015 Jan 15;397(2):191-202
1	J:108725 Zou D, Silvius D, Davenport J, Grifone R, Maire P, Xu PX, Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol. 2006 May 15;293(2):499-512
1*	J:76826 Zuniga A, Quillet R, Perrin-Schmitt F, Zeller R, Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis. Mech Dev. 2002 Jun;114(1-2):51